The clinical utilization of the calculated parameters in predicting anal sphincter complication probabilities was illustrated by applying the best estimate of the parameters to a subset of the patient population. A maximum likelihood fitting was performed to calculate the best estimates of the parameters used by the relative seriality model. A questionnaire was used for assessing the clinical bowel and urinary symptoms. The clinical treatment outcome and the three-dimensional dose distribution delivered to anal sphincter were available for each patient. In this study, 65 patients who received radiation therapy for clinically localized prostate adenocarcinoma are analyzed. Also, the validity of the relative seriality model for this clinical case needs to be examined by associating the clinical follow-up results with the predicted complication rates. The estimation of the parameters that describe the dose-response relations of anal sphincter regarding the clinical endpoints of fecal leakage and blood or phlegm in stools is important in the optimization of prostate cancer radiotherapy.
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